McAuley GE*, Yiu G*, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing. Cell. 2023 Mar 30;186(7):1398-1416.e23. PMID: 36944331. *Authors contributed equally.

Press & Commentary:
UCLA Newsroom UCLA-led study uses base editing to correct mutation that causes rare immune deficiency.
Cell Gene therapy for inborn errors of immunity: Base editing comes to play.
Nature Gene editing holds promise for babies with deadly immune disease.

Yiu G, Rasmussen TK, Tsai BL, Diep VK, Haddon DJ, Tsoi J, Miller GD, Comin-Anduix B, Deleuran B, Crooks GM, Utz PJ. High interferon signature leads to increased STAT1/3/5 phosphorylation in PBMCs from SLE patients by single cell mass cytometry. Frontiers of Immunology. 2022;13:833636. PMID: 35185925; PMCID: PMC8851522.

Haynes WA, Haddon DJ, Diep VK, Khatri A, Bongen E, Yiu G, Balboni I, Bolen CR, Mao R, Utz PJ, Khatri P. Integrated, multi cohort analysis reveals unified signature of systemic lupus erythematous. JCI Insight. 2020 Feb 27;5(4). PubMed PMID: 31971918; PubMed Central PMCID: PMC7101149.

Yiu G, Rasmussen TK, Ajami B, Haddon DJ, Chu AD, Tangsombatvisit S, Haynes WA, Diep V, Steinman L, Faix J, Utz PJ l. Development of Th17-associated interstitial kidney inflammation in lupus-prone mice lacking the gene encoding STAT-1. Arthritis Rheumatol. 2016 May;68(5):1233-44. PMID: 26636548; PMCID: PMC4848130.

Rasmussen TK, Andersen T, Bak RO, Yiu G, Sørensen CM, Stengaard-Pedersen K, Mikkelsen JG, Utz PJ, Holm CK, Deleuran B. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Res Ther. 2015 Jun 9;17:154. PMID: 26055806; PMCID: PMC4504038.

Landrigan A, Yiu G, Agarwal K, Utz PJ. 2012. Therapeutic Toll-like receptor agonists directly influence mouse and human T cell lymphoma cell viability and cytokine secretion. Leuk lymphoma. 2012 Jan;52(1):166-8. PMID: 21780996; PMCID: PMC3339659.

Schaffer BE, Park KS, Yiu G, Conklin JF, Lin C, Burkhart DL, Karnezis AN, Sweet-Cordero EA, Sage J. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res. 2010 May 15;70(10):3877-84. PMID: 20406986; PMCID: PMC2873158.

Eckdahl TT, Brown AD, Hart SN, Malloy KJ, Shott M, Yiu G, Hoopes LL, Heyer LJ. Microarray analysis of the in vivo sequence prefences of a minor groove binding drug. BMC Genomics. 2008 Jan 23;9:32. PubMed PMID: 18215295; PMCID: PMC2254601.

Yiu G, McCord A, Wise A, Kindal R, Hardee K, Kuo A, Shimogawa MY, Cahoon L, Wu M, Kloke J, Hardin J, Mays Hoopes LL. Pathways change in expression during replicative aging in Saccharomyces cerevisiae. J Gerontol A Biol Sci Med Sci. 2008;63(1):21-34. PMID: 18245757; PMCID: PMC2562229.

Yiu G. 2005. Rapid Communications: Antiperspirant Induced DNA damage in Canine Cells by Comet Assay. Journal of Toxicology Mechanisms and Methods, 15(1):25-8. PMID: 20021076.